Life-cycle exposure of Fathead minnows to environmentally relevant concentrations of the B-blocker drug Propranolol

Life-cycle exposure of Fathead minnows to environmentally relevant concentrations of the B-blocker drug PropranololPropranolol is a human pharmaceutical b-blocker that has been detected in municipal wastewater effluents in low concentrations. To assess the potential of this compound to affect fish, Fathead minnow (Pimephales promelas) were exposed for a life cycle in a flow-through system to nominal propranolol concentrations. During the 162-day to 165-day exposure, no significant changes in weights or lengths were seen in Fathead minnows, although the highest concentration of propranolol did cause a 15% decrease in survival of larval and juvenile stage fish compared with controls. At maturity, there were no significant changes in condition factor, liver-somatic index, or secondary sex characteristics in propranolol-exposed male or female fish. Female gonadosomatic index was significantly decreased in fish exposed to the highest concentrations of propranolol, probably because of increased egg-laying. Propranolol exposure caused no effects in Fathead minnows, except at the highest exposure concentration, where there were slight decreases in survival of juvenile minnows, and indications of increased reproduction. The present study is important because it is the first to assess the potential for effects in fish exposed to propranolol for a life cycle.

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Scientific Publication - Life\u2010cycle exposure of fathead minnows to environmentally relevant concentrations of the β\u2010blocker drug propranolol
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